What is the mechanism of action for phenylephrine?

Phenylephrine is an agonist of α1-adrenoceptors. Nasal decongestant action is mediated by activation of α1-adrenoceptors in the arterioles of the nasal mucosa. This causes vasoconstriction, which leads to decreased edema and increased drainage of the sinus cavities.

What does phenylephrine do to the heart?

Phenylephrine is an α-receptor agonist without β-agonist activity. Its administration causes vasoconstriction and an increase in arterial blood pressure, and a decrease in heart rate. Cardiac output may decrease13,27,28 or increase.

Does phenylephrine stop runny nose?

Chlorpheniramine and phenylephrine is a combination medicine used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

How does phenylephrine work vasopressor?

Phenylephrine is a widely used vasopressor in the operating room for the treatment of hypotension. The primary binding target of phenylephrine is the α-adrenergic receptor with the highest affinity for the α1-receptor. Phenylephrine is an α1 selective agonist but may affect β-receptors in high doses.

Which receptor does phenylephrine stimulate?

Phenylephrine is primarily an alpha-1 adrenergic receptor agonist with minimal to no beta-adrenergic activity; therefore, it is ideal for elevating mean arterial pressure.

Does phenylephrine decreased cardiac output?

Conclusion: impact of phenylephrine on cardiac output is related to preload dependency. When the heart is preload independent, phenylephrine boluses induce on average a decrease in cardiac output. When the heart is preload dependent, phenylephrine boluses induce on average an increase in cardiac output.

Is phenylephrine a vasodilator?

Phenylephrine is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. Phenylephrine is available under the following different brand names: Vazculep.

Does phenylephrine work on veins or arteries?

Phenylephrine is a selective α1-adrenergic receptor activator which results in the constriction of both arteries and veins.

Is dopamine a vasodilator?

A unique property of dopamine is that low doses cause vasodilation and decrease systemic blood pressure, whereas high doses cause vasoconstriction and increase systemic blood pressure.

Does phenylephrine do anything?

Phenylephrine is used to relieve nasal discomfort caused by colds, allergies, and hay fever. It is also used to relieve sinus congestion and pressure. Phenylephrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery.

Is phenylephrine a stimulant?

Is phenylephrine a stimulant? Phenylephrine does stimulate alpha-adrenergic receptors which may make it responsible for central nervous system stimulant effects such as restlessness, anxiety, and insomnia.

Is Neosynephrine and phenylephrine the same?

NEO-SYNEPHRINE hydrochloride, brand of phenylephrine hydrochloride ophthalmic solution, is a sterile solution used as a vasoconstrictor and mydriatic for use in ophthalmology.

Will phenylephrine keep me up?

Phenylephrine relieves congestion of the nasal passages and is found in many cold and flu remedies. There is some controversy over whether it works at the dosages usually found in over-the-counter products. Sleeplessness is a common side effect.

Why is pseudoephedrine better than phenylephrine?

Most patients and healthcare providers will agree that Sudafed (pseudoephedrine) is more effective for congestion than its counterpart Sudafed PE (phenylephrine). This is likely due to the fact that the intestines will absorb only about 38% of the amount of Sudafed PE in one tablet, while Sudafed is 100% absorbed.

Is phenylephrine an anti-inflammatory?

What is ibuprofen and phenylephrine? Ibuprofen is a nonsteroidal anti-inflammatory medicine (NSAID). Phenylephrine is a decongestant. Ibuprofen and phenylephrine is a combination medicine used to treat stuffy nose, sinus congestion, headache, fever, and minor aches and pains caused by the common cold or flu.

Is phenylephrine an antihistamine?

What is diphenhydramine and phenylephrine? Diphenhydramine is an antihistamine. Phenylephrine is a decongestant. Diphenhydramine and phenylephrine is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

How long does it take for phenylephrine to start working?

phenylephrine starts working very quickly, usually within 15 minutes. Its full effects happen about 20 to 90 minutes after your dose.

Does phenylephrine cause rebound congestion?

Side effects. Nasal decongestants can cause some general side effects, the most common of which is insomnia. Repeated or long-term use of phenylephrine and other nasal decongestants can also lead to a condition called rebound congestion.