What is the most common cause of high platelet count?

Infection. In both children and adults, infections are the most common cause of an elevated platelet count. 1 This elevation can be extreme, with platelet counts greater than 1 million cells per microliter.

Is high platelet count serious?

High platelet counts can lead to blood clots. This can trigger uncomfortable symptoms, as well as medical emergencies, such as seizures or strokes. Additional complications include acute leukemia, as well as other cancers.

What cancers cause high platelets?

In the present study, lung and colorectal cancers were particularly associated with high-normal platelet counts.

What are the symptoms of high platelets?

The signs and symptoms of a high platelet count are linked to blood clots and bleeding. They include weakness, bleeding, headache, dizziness, chest pain, and tingling in the hands and feet.

What should I do if my platelet count is high?

Your doctor might prescribe platelet-lowering drugs primarily in the form of hydroxyurea (Droxia, Hydrea) or interferon alfa (Intron A). Platelets can be removed from your blood by a procedure that’s similar to dialysis.

What autoimmune disease causes high platelets?

Hughes syndrome, or antiphospholipid antibody syndrome (APS), is an autoimmune condition that causes thickening of the circulating blood. The immune system produces abnormal blood proteins called antiphospholipid antibodies, which cause blood platelets to clump together.

What is the alarming level of platelets?

A count lower than 150,000 platelets per microlitre of blood is considered to be thrombocytopenia, which means a lower than normal platelet count. Below 50,000 is a seriously low platelet count. Below 10,000 is considered severe thrombocytopenia, with a risk of internal bleeding.

Can stress cause high platelets?

Research gives hint that platelets activation and reactivity is increased by mental stress. This leads to enhanced cross talk with the immune system via paracrine secretion, receptor interaction and formation of platelet leucocyte-aggregates.

What causes a sudden increase in platelets?

Too many platelets can lead to certain conditions, including stroke, heart attack or a clot in the blood vessels. There are two types of thrombocytosis: primary and secondary. Primary thrombocytosis is a disease in which abnormal cells in the bone marrow cause an increase in platelets.

How can I lower my mean platelet naturally?

Decreasing MPV
  1. Address Underlying Conditions. A high MPV is often due to an underlying medical condition. …
  2. Lose Weight. Diabetes and obesity are associated with higher MPV [21, 19]. …
  3. Check Vitamin D Levels. Check your vitamin D levels. …
  4. Stop Smoking.

Can high platelets cause fatigue?

Essential thrombocythemia (throm-boe-sie-THEE-me-uh) is an uncommon disorder in which your body produces too many platelets. Platelets are the part of your blood that sticks together to form clots. This condition may cause you to feel fatigued and lightheaded and to experience headaches and vision changes.

Do platelets fight inflammation?

Platelets sense and respond to local dangers (infectious or not). Platelets, therefore, mediate inflammation, express and use receptors to bind infectious pathogen moieties and endogenous ligands, among other components.

Can medication cause high platelets?

Adrenalin was one of the first drugs noticed to cause platelet elevations, probably due to demargination of platelets in the pulmonary vasculature. Vinca alkaloids have the most convincing data to show that they can induce thrombocytosis through their thrombocyte-stimulating properties.

How long can you live with thrombocytosis?

The life expectancy of patients with essential thrombocytosis (primary thrombocythemia) is nearly that of the healthy population. Median survival is approximately 20 years. For patients younger than age 60 years, median survival is 33 years.

Does high platelets mean inflammation?

Mild to moderately elevated platelet counts are commonly seen when chronic inflammation is present. In other cases a high platelet count can signal a more serious blood problem known as a myeloproliferative disorder (abnormal growth of blood cell elements within the bone marrow).

Can inflammation cause platelets to rise?

The accumulation of immune cells in inflamed tissue can also lead to the generation of adenosine diphosphate (ADP), which activates platelets and promotes the degranulation of both dense granules and α-granules.

What is a normal platelet count for a woman?

A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. Having more than 450,000 platelets is a condition called thrombocytosis; having less than 150,000 is known as thrombocytopenia. You get your platelet number from a routine blood test called a complete blood count (CBC).

Can vitamin D deficiency cause high platelet count?

Conclusions: This study indicates, for the first time, that vitamin D deficiency is associated with a parallel increase in platelet number, suggesting that higher platelet numbers may be one of the possible mechanisms leading to a greater cardiovascular risk in obese subjects.