What is the principle of disintegration?

Disintegration is defined as that state in which no residue of the unit under test remains on the screen of the apparatus or, if a residue remains, it consists of fragments of disintegrated parts of tablets component parts such as insoluble coating of the tablets or of capsule shells, or of any melted fatty substance …

Why do we perform disintegration?

Why do we do it? Like dissolution testing, Disintegration is often a pharmacopoeial testing requirement for the vast majority of solid dosage forms. It provides critical safety data on medicine bioavailability in the body without having to utilise in vivo methods.

What is disintegration process?

Disintegration is a process of breaking down a substance into tiny fragments to improve its solubility in a solvent. The process is used predominantly in pharmaceutical and chemical industries. Dissolution, on the other hand, is a process through which solutes dissolve in a solvent.

Which apparatus is used for disintegration test?

Disintegration Tester is a solid state instrument designed for the accurate estimation of disintegration time of tablets as per IP/USP standards. The instrument is designed to test two batches of six tablets, simultaneously. The unit is extremely useful for pharmaceutical industries.

What is disintegrating agent?

Disintegrating agents or disintegrators or disintegrants are the substances which are added to an oral solid dosage form such as tablet, beads, pellet, granule as well as capsule to promote its rapid disintegration or break down into small particles after administration for facilitating rapid dissolution into GI fluid.

What is disintegration time?

Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions. … In other words DT (disintegration time) is measuring the break down of a dosage form and dissolution is measuring the medicine being solubilized in the media.

What is 5.3 disintegration test?

11. This test is provided to determine whether tablets or capsules disintegrate within the prescribed time. 12. when placed in a liquid medium under the experimental conditions presented below.

What is disintegration test Slideshare?

Disintegration test (U.S.P.) :  For a medicine to be readily available to the body , it must be in solution.  For most tablets, the first important step toward solution is break down of the tablet into smaller particles or granules, a process called disintegration.

What is the temperature limit for operating disintegration test apparatus?

Why the temperature specification for disintegration test apparatus is 37±2 ºC. Why it is different from that of dissolution test apparatus (37±0.5 ºC)? Though both mimics the body conditions to which the formulation will be exposed after administration.

What is disintegration time for uncoated tablet?

uncoated tablets pass the test if each of the six uncoated tablets disintegrates3 in not more that 45 minutes; plain coated tablets pass the test if each of the six plain coated tablets disintegrates in not more than 60 minutes.

What is disintegration time of film coated tablets?

Unless otherwise stated in the individual monograph film-coated tablets disintegrate within 30 minutes and other coated tablets disintegrate within 60 minutes.

Is disintegration test required for chewable tablets?

BP2008: From the general monograph for tablets: “Chewable tablets are prepared to ensure that they are easily crushed by chewing”. “Chewable tablets are not required to comply with the test [for disintegration]”.

What is the USP requirement for disintegration of uncoated tablets?

Uncoated tablets, except soluble tablets, dispersible tablets, effervescent tablets and tablets for use in the mouth comply with 5.3 Disintegration test for tablets and capsules. Operate the apparatus for 15 minutes, unless otherwise specified in the individual monograph, and examine the state of the tablets.

What is the purpose for the enteric coating on a tablet?

Enteric coating is valuable in placing a barrier over a medication to prevent it from dissolving until after it passes through the stomach. The word enteric means relating to, or being within the intestine.

Why albendazole is chewed before swallowing?

The coating ensures the tablet disintegrates in the small intestine instead. If you chew an enterically coated tablet, the medicine will not be absorbed properly and the medicine may be ineffective. Tablets designed to be chewed have this indicated on their packaging.

What is the disintegration time for hard gelatin capsule?

The disintegration time of conventional hard gelatin capsules (HGC) was reduced from 91 to 39 s by introducing 6-10 small holes (diameter =25-50 microm) into the capsule shell. Vacuum-drying of conventional hard gelatin capsules resulted in brittle capsules, which broke rapidly in the oral cavity.

Do modified release tablets disintegrate?

Diffusion systems

Reservoir devices coat the medicine with polymers and in order for the reservoir devices to have sustained release effects, the polymer must not dissolve and let the medicine be released through diffusion.

Which is better albendazole or mebendazole?

Both agents were equally very effective (100% cure rate) in treating ascariasis. Albendazole was clearly more active than mebendazole against hookworm infections, both in terms of egg reduction rate (92.8% vs. 62.4%) and cure rate (81.8% vs. 17.2%).

What happens to worms after taking albendazole?

Albendazole is used to treat infections caused by worms. It works by keeping the worm from absorbing sugar (glucose), so that the worm loses energy and dies.

What happens after taking albendazole?

Nausea, vomiting, abdominal pain, headache, or temporary hair loss may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Which is the best worm medicine?

Treatment. The most commonly used anti-worm products to treat intestinal worms (threadworms, roundworms and hookworms) are pyrantel, albendazole or mebendazole.

What is the best medicine for worms in humans?

Mebendazole is a type of medicine for treating worms. It is used mainly for infections of the gut such as threadworms (sometimes known as pinworms) and other less common worm infections (whipworm, roundworm and hookworm). You can buy mebendazole from a pharmacy. It’s also available on prescription.

Which is more effective albendazole or ivermectin?

Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and a highly effective single dose treatment for S.