Why does salicylic acid have a higher Rf than aspirin?

Due to higher interaction among molecules, salicylic acid is less attracted to the stationary phase and will move further up the plate thus having a higher Rf value than the standard salicylic acid and a closer Rf value to the acetylsalicylic acid in the reaction mixture.

What is the Rf value?

The Rf (retardation factor) value is the ratio of the distance moved by the solute to the distance moved by the solvent. The term originates in chromatography, where it was observed that a particular compound will always travel the same distance in a particular solvent, as long as conditions are constant.

How do you calculate Rf?

What is the Rf value of Tylenol?

The Rf values of the isolated acetaminophen, pure acetaminophen and Excedrin were all within 0.06. This is most likely due to the contamination of the TLC plate with Excedrin.

What is a good Rf value?

A desirable Rf value lies between 0.3 and 0.7, since it is likely that other compounds present in the mixture will be visible on the TLC plate when the Rf is in this range. Identification of a solid using thin layer chromatography (TLC):

What are Rf signals?

A radio frequency (RF) signal refers to a wireless electromagnetic signal used as a form of communication, if one is discussing wireless electronics. Radio waves are a form of electromagnetic radiation with identified radio frequencies that range from 3kHz to 300 GHz.

What is the Rf value of ibuprofen?

Rf values were found to be 0.40, 0.94, 0.66, 0.27, 0.83 for ibuprofen, 4-isobutylacetophenone, famotidine, famotidine acid and basic degradation products, respectively.

What is the Rf value of naproxen?

The mobile phase ethyl acetate: methanol: ammonia 25% (85:15:5 v/v) was used for the separation of the components of mixtures (I) and (II) with Rf values of 0.16 for naproxen, 0.4 for diflunisal, 0.77 for paracetamol and 0.32 for chlorzoxazone.

What is the Rf value of caffeine?

0.63
The Rf value of caffeine standard was 0.63, and every sample showed similar value with caffeine standard, indicating that all samples contain caffeine.

Is caffeine more polar than aspirin?

Acetaminophen has a phenol and amide function group, but caffeine has multiple amide functional groups; therefore, acetaminophen is more polar than aspirin and less polar than caffeine.

What do Rf values mean in TLC?

In thin-layer chromatography, the retention factor (Rf) is used to compare and help identify compounds. The Rf value of a compound is equal to the distance traveled by the compound divided by the distance traveled by the solvent front (both measured from the origin).

Is naproxen an anti inflammatory medicine?

Naproxen is a nonsteroidal anti-inflammatory medicine (NSAID) used to relieve symptoms of arthritis (eg, osteoarthritis, rheumatoid arthritis, or juvenile arthritis) such as inflammation, swelling, stiffness, and joint pain.

What makes acetaminophen more polar than aspirin?

Acetaminophen has two hydrogen bonds and one dipole-dipole making it more polar than Aspirin, Phenacetin, and Ibuprofen.

Is salicylic acid more polar than aspirin?

The difference between the two is that aspirin is salicylic acid with the free OH of salicylic acid having been esterified. Both compounds still have the -COOH group. So, it comes down to comparing -OH to -OC=OCH3. The -OH group is more polar than the ester so salicylic acid is more polar than aspirin.

Is aspirin soluble in water?

Aspirin is only slightly soluble in water so if you add it to the reaction mixture the product would rather clump together than be in the water phase. This causes the solid to begin to form or ‘precipitate’.

Which is more polar aspirin or ibuprofen?

Based on the rate of migration, one can conclude that the acetaminophen, aspirin and caffeine are polar and prefer to be on the stationary phase while the naproxen sodium, unknown and ibuprofen are less polar with weak bonds.

Is caffeine polar or non polar?

Yes, caffeine is a polar molecule. The Oxygen and Nitrogen molecules have a stronger polarity than Carbon, allowing them to slightly pull the electrons towards them in their covalent bond. This will give those atoms a slightly negative charge while giving the Carbon a positive charge.

Is caffeine the most polar?

Ibuprofen is least polar and Caffeine is most polar. caffeine contains two amide groups, two amine groups and an alkene group.

Is aspirin non polar?

Aspirin is a polar molecule with dipole-dipole attraction bonds and an -OH (hydroxyl) segment as part of a carboxylic acid group. This makes it easily dissoluble in other polar liquids, such as water (H2O) and blood plasma.

Which is more polar aspirin or paracetamol?

Acetaminophen is more polar than aspirin because it has more sites for hydrogen | Course Hero.